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KMID : 1094720200250040543
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Biotechnology and Bioprocess Engineering
2020 Volume.25 No. 4 p.543 ~ p.550
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Anti-inflammatory Effects of Lecania gerlachei Extract Collected from the Antarctic King Sejong Island
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Min Seul-Ki
Kim Jung-Eun
Hong Ju-Mi
Yim Joung-Han
Park Hyun
Youn Ui-Joung
Han Se-Jong
Kim Il-Chan
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Abstract
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Chronic inflammation is the cause of various diseases such as rheumatoid arthritis and asthma, with a large number of people suffering from them. There have been many reports that even link cancer to inflammation, so the development of sophisticated and powerful drugs continues to be in demand. Here we demonstrate that the methanol extract of Lecania gerlachei (LGME), a lichen member found in the extreme Antarctic environment, exhibits anti-inflammatory activities. Treatment of lipopoly-saccharide (LPS) stimulated Raw 264.7 murine macrophage cells with LGME reduced nitric oxide (NO) immune modulator production, and also down-regulated inducible nitric oxide synthase (iNOS), pro-inflammatory interleukin 6, 1ß and 1α (IL-6, IL-1ß and IL-1α), and tumor necrosis factor α (TNF-α) at both transcript and protein levels, in a concentration dependent manner. Furthermore, it was found that these effects were mediated by nuclear factor kappa B (NF-κB) signaling inhibition. Thus, our findings may contribute towards the development of novel inflammatory drugs.
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KEYWORD
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Lecania gerlachei, lichens, Antarctica, antiinflammatory properties, nuclear factor kappa B (NF-κB) pathway
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